Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Alternative form of
pro-peptide .
Etymologies
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Examples
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The mature growth factor dimer is structurally similar to other members of the TGF-β family [11]; however the structural characteristics of MstnPP or the propeptide region remain undetermined.
PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010
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Davies MV, Pearson AA, Wang JH, Hewick RM, et al. (2002) The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum.
PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010
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The myostatin propeptide that lies N-terminal to the mature domain has been proposed to have a chaperone-like function in the correct folding of the mature domain
PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010
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Liang L, Wang S, Ratovitski T, Holmstrom J, et al. (2004) Characterization and identification of the inhibitory domain of GDF-8 propeptide.
PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010
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The RSRR furin proteolysis sequence that separates the propeptide from the growth factor domain is shown in bold.
PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010
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The absolute negative value at 200 nm implies a degree of intrinsic disorder exists in the structure which may be functionally significant due to the different roles suggested for the propeptide region of the myostatin precursor, requiring flexibility in the N-terminal domain.
PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010
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The propeptide region plays at least two important functions.
PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010
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Myostatin remains latent until a second cleavage event immediately N-terminal to aspartate 76 of the propeptide region, most probably by metalloproteinases, that disrupts the association
PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010
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Second, the N-terminal propeptide plays a regulatory role after cleavage, remaining non-covalently associated with the mature dimer to form a latent complex which is exported from the cell
PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010
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The mature growth factor dimer is cleaved from the propeptide region by furin convertase proteolysis in the endoplasmic reticulum (ER) at a conserved RSRR sequence
PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010
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