protofibril

Four of these keratin springs are twisted together to form a rope, called a protofibril, and eleven of these protofibrils are twisted together to form a thicker rope, called a microfibril.

Ancient Egyptian hair dye - technology finally catches up Carla 2006

Four of these keratin springs are twisted together to form a rope, called a protofibril, and eleven of these protofibrils are twisted together to form a thicker rope, called a microfibril.

Archive 2006-10-01 Carla 2006

Rochet JC, Bieganski RM, Lansbury PT Jr (2001) Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct.

PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010

When subjected to a slightly acidic pH and elevated temperature, the protofibril-like aggregates form straight and unbranched amyloid fibrils that are 15 nm in diameter and exhibit higher order amyloid structures such as twists and bundles.

PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010

When subjected to a slightly acidic pH and elevated temperature, the protofibril-like aggregates form straight and unbranched amyloid fibrils that are 15 nm in diameter and exhibit higher order amyloid structures such as twists and bundles.

PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010

Although elevated temperature has been used to produce mature MstnPP fibrils quickly in this study, a physiological temperature allows protofibril and mature fibril formation over an extended time period; by comparison, fibril formation is expected to occur over many years sIBM is characterised by amyloid aggregation of the Aβ protein and severe muscle atrophy

PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010

Hartley DM, Zhao C, Speier AC, Woodard GA, Li S, et al. (2008) Transglutaminase induces protofibril-like amyloid-β protein assemblies that are protease-resistant and inhibit long-tem potentiation.

PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010

These in vitro results show that MstnPP is capable of amyloid protofibril and fibril formation, supporting a role for misfolding of the myostatin precursor in the pathogenesis of sIBM.

PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010

Circular dichroism spectroscopy reveals that MstnPP undergoes a number of structural transitions through aggregation to amyloid protofibril and fibril formation that initiate at a physiologically relevant temperature.

PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010

E. coli inclusion bodies, a population of MstnPP spontaneously misfolds into amyloid protofibril-like aggregates that can be visualised using electron microscopy and bind the amyloid-specific dye thioflavin T.

PLoS ONE Alerts: New Articles Carlene S. Starck et al. 2010