pteridines

I had been assigned quite early to work on the purines and, with the exception of a few deviations into the pteridines and into some other condensed pyrimidine systems, the remainder of my work concentrated almost completely on the purines.

Gertrude B. Elion - Autobiography 1989

It was my assignment to work on purines, pteridines, and some other condensed pyrimidine systems.

Nobel Lecture The Purine Path To Chemotherapy 1988

Km: 0.240 mM [40]; Km: 0.14 mM [44]; < 1,5,18 > Km: 0. 2-1 mM, dependent on the concentrations of a-ketoglutarate and Fe2+, reduced pteridines can partially replace ascorbate [48]; recombinant enzyme, Km: 0.3 mM [59]; Km for wild-type en - zyme tetramer:

Recently Uploaded Slideshows arab2000.forumpro.fr@slideshare.net(arab2000.forum 2009

< 1, 3, 5, 18 > re - quirement [1-3, 28, 48]; pure enzyme, high specificity, dithiothreitol and l-cysteine are the only compounds that give more than 10% of the activity found with the optimal ascorbate concentration, some reduced pteridines give values ranging from 3 to 9% [1];

Recently Uploaded Slideshows arab2000.forumpro.fr@slideshare.net(arab2000.forum 2009