Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun genetics A
DNA gene copied back fromRNA byreverse transcription
Etymologies
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Examples
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In addition, the Makorin gene family counts at least 3 functional members in the mouse including, of interest, a bona fide functional retrogene, which is transcribed, conserved in mammals, and encodes the Makorin-3 protein, as well as numerous pseudogenes, which can complicate molecular and sequence analysis.
Rumors of pseudogenes' demise greatly exaggerated, new study says - The Panda's Thumb 2006
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These characteristics led researchers to conclude that the extra gene is a so-called retrogene that was inserted into the dog genome some time after the ancestor of modern dog breeds diverged from wolves.
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Owing to these characteristics, the researchers concluded that the extra gene is a so-called retrogene that was inserted into the dog genome some time after the ancestor of modern dog breeds diverged from wolves.
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The element -- a so-called retrogene -- changes the expression of IGF-1 and gives the dogs the distinctive short, bowed forelimbs of chondrodysplasia.
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There are at least seven different known instances of common retrogene insertions between chimps and humans.
Signature in the Cell: self-contradiction and repetition - The Panda's Thumb 2009
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Still, there were some reasons for skepticism – for instance, the Mkrn1-p1 retrogene, despite its purported crucial role in mice, is absent from the genome of all other mammals tested, including closely related rats.
Rumors of pseudogenes' demise greatly exaggerated, new study says - The Panda's Thumb 2006
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There is some idea that retrogene formation may be favored in testes due to hyperactivity of transcription during male meiosis.
Human Evolution: It's all in the testes - The Panda's Thumb 2005
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But in every single case, the corresponding retrogene was expressed in testes only.
Human Evolution: It's all in the testes - The Panda's Thumb 2005
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VonHoldt BM, Quignon P, Margulies EH, Shao S, et al. (2009) An expressed fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs.
PLoS ONE Alerts: New Articles Danika Bannasch et al. 2010
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The retrogene is found in so many of these small dogs that Ostrander thinks it inserted into the genome of a common ancestor before the dogs separated into 20 different breeds or so.
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