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Examples
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The single-molecule sequencing method the HeliScope is based on has proved extremely difficult to build into a machine at a competitive price.
The $1,000 Genome Kevin Davies 2010
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Moreover, it was the first report of decoding a human genome by single-molecule sequencing and a timely shot in the arm for embattled Helicos.
The $1,000 Genome Kevin Davies 2010
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“Electrical, single-molecule sensing on an instrument the size of a laptop is going to transform a lot of areas, not just DNA sequencing.”
The $1,000 Genome Kevin Davies 2010
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Balasubramanian said he could have submitted the same story five years earlier: “Steve Quake was the first to publish and will say he invented single-molecule sequencing, but we had the first patent on it.”
The $1,000 Genome Kevin Davies 2010
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In fact, Bayley stayed away from DNA sequencing as a professional courtesy to Branton, making progress in chemically modifying the hemolysin to use it as a single-molecule sensor for drugs, chemicals, and metal ions.
The $1,000 Genome Kevin Davies 2010
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Michael J. Levene et al., “Zero-mode waveguides for single-molecule analysis at high concentrations,” Science 299 2003, 682–686.
The $1,000 Genome Kevin Davies 2010
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Using genetic sequences from 33,996 Americans, Canadians and Europeans, researchers in the present study identified three sections of DNA where a single-molecule mutation increased or decreased the risk for vitamin D deficiency.
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Pleasure time may not be what you want to devote to reading Chu's latest article in the journal Nature: "Subnanometre single-molecule localization, registration and distance measurements."
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In spring 2003, another competitor emerged 6,000 miles away when Steve Quake and colleagues at Caltech published a paper on a method for single-molecule DNA sequencing that was similar in some ways to what Solexa had been developing, only the Brits had chosen not to publish.
The $1,000 Genome Kevin Davies 2010
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Brown remembered Swerdlow listing all the cumulative inefficiencies of single-molecule sequencing on a whiteboard.
The $1,000 Genome Kevin Davies 2010
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