ssRNA

In the lab, writes its inventor, Todd Rider of MIT's Lincoln Laboratory, "we have demonstrated that Dracos are effective against viruses with DNA, dsRNA, positive-sense ssRNA, and negative-sense ssRNA genomes; enveloped and nonenveloped viruses; viruses that replicate in the cytoplasm and viruses that replicate in the nucleus; human, bat and rodent viruses; and viruses that use a variety of cellular receptors."

Modifying Mother Nature to Kill Nasty Viruses Matt Ridley 2011

Family Orthomyxoviridae, within which the five influenza genera exist, are all are negative sense, single-stranded, segmented RNA viruses (ssRNA -).

Swine Flu-- Normal or Malignant? 2009

As evidence of our bullishness on ssRNA approaches, Atlas has also recently created another play aimed at targeting long non-coding RNAs

Forbes.com: News Bruce Booth 2011

These ssRNA drugs can target many types of RNA, but one of the most exciting are the abundant non-coding RNAs like microRNA

Forbes.com: News Bruce Booth 2011

The company, currently in stealth mode, will be leveraging lots of the emerging insight around the pharmacology of ssRNA approaches.

Forbes.com: News Bruce Booth 2011

Its worth noting the other players are also pushing the field of ssRNA approaches to miR-based targets.

Forbes.com: News Bruce Booth 2011

Another big piece of ssRNA news is right around the corner hopefully: FDA approval of Isis'

Forbes.com: News Bruce Booth 2011

Its become clear over the past few years that these ssRNA drugs can block these microRNAs very efficiently.

Forbes.com: News Bruce Booth 2011

Genome: infectious,11kb ssRNA, +ve polarity  Virus is inactivated by heat and disinfectant,  containing detergent or lipid solvent.

Recently Uploaded Slideshows 2009

These viruses have a linear positive-sense ssRNA genome of ~26-27 kb, encoding a large replicase polyprotein that is expressed from the genomic RNA, and several additional proteins that are expressed from a nested set of 3'-coterminal subgenomic RNAs.

BioMed Central - Latest articles Andrew Firth 2009