Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun organic chemistry Reaction with, or conversion to a
sulfoxide
Etymologies
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Examples
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Then a high temperature simulation was run at 380 K for the different sulfoxidized proteins yielding qualitatively analogous results for the three variants (sulfoxidation at M206, M213 and at both sites).
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N.; Battistel, E.; Bianchi, D.: Effects of substrate structure on the enantioselectivity and stereochemical course of sulfoxidation catalyzed by cyclohexanone mono - oxygenase.
Recently Uploaded Slideshows arab2000.forumpro.fr@slideshare.net(arab2000.forum 2009
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These changes are also observed when the sulfoxidation is placed at M206 and at both, M206 and M213.
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This non quantitative but state signature characteristic suggested that sulfoxidation of M213 could act as the postulated covalent trigger for the pathological conversion.
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Sc exhibits as covalent signature the sulfoxidation of M213.
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Our previous studies using a combination of protein chemistry and immunological tools have shown that sulfoxidation of M213 constitutes indeed a covalent signature for PrP
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Finally, in the absence of experimental evidences supporting a selective modification, we analyzed the effect of the double sulfoxidation replacing the sulfur atoms of M206 and M213 side chains by sulfoxide groups.
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Our results suggest that the sulfoxidation of Helix-3 methionines might be the switch for triggering the initial α-fold destabilization required for the productive pathogenic conversion.
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Therefore we performed the analysis of the effect of sulfoxidation at M206 on the structure and stability of the α-fold of HuPrP (125-229).
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The sulfoxidation-induced structural destabilization is a hallmark of conserved Helix-3 methionines
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