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Examples
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WEINBERG: It's now becoming increasingly clear that tumors actually send signals to the bone marrow, urging the bone marrow to ramp up the production of cells that are then spilled into the circulation, then become available for recruitment by the tumor cells, being used by the tumor cells to construct the tumor-associated stroma.
Targeting Cancer Gangs Jonathan D. Rockoff 2010
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WEINBERG: It's now becoming increasingly clear that tumors actually send signals to the bone marrow, urging the bone marrow to ramp up the production of cells that are then spilled into the circulation, then become available for recruitment by the tumor cells, being used by the tumor cells to construct the tumor-associated stroma.
Targeting Cancer Gangs Jonathan D. Rockoff 2010
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WEINBERG: It's now becoming increasingly clear that tumors actually send signals to the bone marrow, urging the bone marrow to ramp up the production of cells that are then spilled into the circulation, then become available for recruitment by the tumor cells, being used by the tumor cells to construct the tumor-associated stroma.
Targeting Cancer Gangs Jonathan D. Rockoff 2010
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WEINBERG: It's now becoming increasingly clear that tumors actually send signals to the bone marrow, urging the bone marrow to ramp up the production of cells that are then spilled into the circulation, then become available for recruitment by the tumor cells, being used by the tumor cells to construct the tumor-associated stroma.
Targeting Cancer Gangs Jonathan D. Rockoff 2010
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A growing number of tumor-associated antigens have been identified.
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Vaxfectin R has achieved similar effects with protein-based vaccines for infectious diseases and with tumor-associated antigen peptides for cancer applications.
unknown title 2011
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To overcome this poor responsiveness, recombinant poxvirus vectors, including vaccinia, fowlpox and modified vaccinia Ankara (MVA), can be genetically engineered to express one or more tumor-associated antigens to greatly enhance the immune system's ability to recognize and destroy cancer cells bearing any of the targeted antigens. ® and CV-301 are prime-boost vaccines, sequentially combining two different poxviruses (vaccinia and fowlpox).
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These extensive clinical studies suggest a favorable safety and tolerability profile for poxvirus-based vaccines along with immunologic responses directed against the relevant tumor-associated antigens.
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Furthermore, infection-fighting tumor-associated macrophages and monocytes (TAMs) that flood the brain in an effort to battle tumor cells can indirectly support tumor growth through the release of agents that lead to inflammation and the growth of blood vessels.
PhysOrg.com - latest science and technology news stories 2010
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However, data also suggest that, to be effective, an antitumor vaccine should generate strong cellular immune responses to the target tumor-associated antigens.
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