Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A particular
drug used to treatcancer .
Etymologies
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Examples
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Paul Marks and Ronald Breslow at Columbia created a small molecule, called vorinostat, that blocks the action of the enzymes that tamper with DNA's packaging, thus turning inactivated genes back on.
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The data in the publication in the British Journal of Cancer suggest that sapacitabine given in combination with HDAC inhibitors, such as vorinostat or sodium valproate, results in significantly enhanced cell death in AML cells and cell lines derived from other tumor tissues, including cutaneous T-cell lymphoma (CTCL), non-Hodgkins lymphoma (NHL) and non-small cell lung cancer (NSCLC).
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As a reference standard for the comparison of results, we used suberoylamide hydroxamic acid (SAHA; also referred to as "vorinostat"), a non-specific inhibitor of both classes of HDACs when used in the upper-nanomolar/micromolar range of concentrations [15].
Recently Uploaded Slideshows mabasta 2009
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Measurement of the HDAC isoform selectivity profile of sodium valproate, sodium butyrate, and vorinostat revealed the common inhibition of class I HDACs
Naturejobs - All Jobs Mark Kilgore 2010
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Results from two Phase 1 studies of ZOLINZA (vorinostat), Merck's oral histone deacetylase (HDAC) in ...
THE MEDICAL NEWS 2010
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The U.S. Food and Drug Administration (FDA) has approved Zolinza (vorinostat) capsules for the treat ...
THE MEDICAL NEWS 2010
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Results from two investigational Phase I trials of ZOLINZA (vorinostat) in combination with bortezom ...
THE MEDICAL NEWS 2010
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(HDAC1, 2, 3, 8) with little effect on the class IIa HDAC family members (HDAC4, 5, 7, 9) and inhibition of HDAC6 only by vorinostat.
Naturejobs - All Jobs Mark Kilgore 2010
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Co. 's vorinostat, a treatment for T-cell lymphoma and the only FDA-approved drug that targets acetylation-modifying enzymes, faced challenges because of poor selectivity, Schreiber notes.
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Co. 's vorinostat, a treatment for T-cell lymphoma and the only FDA-approved drug that targets acetylation-modifying enzymes, faced challenges because of poor selectivity, Schreiber notes.
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