Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun An
anticoagulant drug once proposed as a replacement forwarfarin but withdrawn due tohepatotoxicity risks.
Etymologies
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Examples
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An AstraZeneca PLC drug called ximelagatran came close, but failed when it proved toxic to the liver.
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I had my hopes that ximelagatran would be the replacement for warfarin.
This time,new oral anticoagulants may well make it to the market james gaulte 2008
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I had my hopes that ximelagatran would be the replacement for warfarin.
Archive 2008-06-01 james gaulte 2008
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Lincoff told heartwire that, undoubtedly, hangovers from the ximelagatran experience were making people nervous.
theHeart.org 2009
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The signal with ximelagatran "was clearly more frequent than any potential signal we are dealing with here, but the FDA wanted to be cautious," Lincoff notes.
theHeart.org 2009
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The experience with ximelagatran had indicated that monotherapy with the drug was associated with higher early rates of recurrent VTE relative to warfarin, Schulman and colleagues wrote.
MedPageToday.com - medical news plus CME for physicians 2009
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The researchers said no liver toxicity was seen with the drug, in contrast to another oral thrombin inhibitor, ximelagatran.
MedPageToday.com - medical news plus CME for physicians 2009
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"We know that with warfarin and, to some extent, direct thrombin inhibitors like ximelagatran, more potent anticoagulation can reduce those events, but, as with all effective anticoagulants, they increase bleeding."
theHeart.org 2008
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