from The Century Dictionary.

  • noun A substance from which an enzym may be formed by internal change. Also zymogene.

from the GNU version of the Collaborative International Dictionary of English.

  • noun (Physiol. Chem.) A mother substance, or antecedent, of an enzyme or chemical ferment; -- applied to such substances as, not being themselves actual ferments, may by internal changes give rise to a ferment.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry A proenzyme, or enzyme precursor, which requires a biochemical change (i.e. hydrolysis) to become an active form of the enzyme.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • noun any of a group of compounds that are inactive precursors of enzymes and require some change (such as the hydrolysis of a fragment that masks an active enzyme) to become active


Sorry, no etymologies found.


Help support Wordnik (and make this page ad-free) by adopting the word zymogen.


  • Trypsin itself then cleaves lysine peptide bonds, and so, once a small amount of trypsin is generated, it participates in cleavage of its own zymogen, generating – more trypsin!

    Vacuity of ID: Comments on Irreducible Complexity - The Panda's Thumb

  • Redman, David Sabatini and Yutaka Tashiro; it led to the characterization of the zymogen granules and to the discovery of the segregation of secretory products in the cisternal space of the endoplasmic reticulum.

    George E. Palade - Autobiography

  • It may very likely produce the same change in the membrane that is caused by the entrance of the spermatozoon under normal circumstances -- membrane formation may be necessarily coincident with the liberation in the egg of some zymose which arises from a pre-existent zymogen.

    Science and Morals and Other Essays

  • Protein C is a serine protease blood coagulation factor that circulates as an inactive zymogen and is activated by thrombin during blood coagulation to form activated protein C APC.

  • Vande Haar penned a 12-verse epic in which he manages to rhyme words like "phospholipids," "hemorrhage" and "zymogen." - latest science and technology news stories

  • As of this typing, it contains 13 scrolling screens of active netlabels (OK, I'm on a netbook; your scrolling may vary), from the Guadalajara, México-based (plus a bunch whose monikers start with numbers or symbols).

    Boing Boing

  • This prodomain maintained MMP-2 as a zymogen and this loop is cleaved by MMP-14 after MMP-2 secretion given active form.

    PLoS ONE Alerts: New Articles

  • In such a model, cells secrete MMP-2 as an inactive zymogen (Pro-MMP-2) containing 8 disulphide bonds

    PLoS ONE Alerts: New Articles

  • This enzyme contains an amino-terminal signal sequence (Pre) that directs it to the secretory pathway via the endoplasmic reticulum (ER) and a propeptide (Pro) that maintains it as inactive zymogen

    PLoS ONE Alerts: New Articles

  • The loss of vacuole acidification in V-ATPase mutants prevents zymogen activation and causes defects in the proteolytic function of the vacuole

    PLoS ONE Alerts: New Articles


Log in or sign up to get involved in the conversation. It's quick and easy.