Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A functional group derived from
adenosine monophosphate , also known as 5-adenylic acid
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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Signaling by CAR1 during aggregation leads to the activation of effector enzymes such as adenylyl cyclase (ACA) and extracellular signal-related kinase 2 (ERK2) by both G protein-dependent and - independent mechanisms.
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Iseki M et al., A blue-light-activated adenylyl cyclase mediates photoavoidance in Euglena gracilis Nature, 2002, 415, 1047-1051
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Iseki M et al., A blue-light-activated adenylyl cyclase mediates photoavoidance in Euglena gracilis Nature, 2002, 415, 1047-1051
Blind Mice vs Behe; the Evolution of Vision - The Panda's Thumb 2006
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Sutherland and Rall had already shown in brain slices that several neurotransmitters known to exist in the brain could increase the concentrations of cAMP by activating the enzyme adenylyl cyclase that converted ATP to cAMP.
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Schwartz and Cedar next found that the transmitter serotonin could also increase cAMP, providing the initial evidence that serotonin might activate an adenylyl cyclase in
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We found that catecholamine effects on adenylyl cyclase activation in both heart and liver preparations were, indeed, due to beta adrenergic effects as shown by the relative potencies of l-isoproterenol, l-epinephrine and l-norepinephrine with inhibition by dichloroisoproterenol and failure of alpha blockers and agonists to have effects.
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Prior to this the view of Sutherland was that receptors and adenylyl cyclase were a single macromolecule or a tightly associated complex in cell membranes.
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I also found that acetylcholine and other cholinergic agents inhibited adenylyl cyclase preparations, the first description of hormones, inhibiting cyclic AMP formation.
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My work as a student and the work of others questioned this hypothesis and suggested that different receptors for this growing list of hormones must be coupled to adenylyl cyclase in yet to be determined complex ways (see Gilman's and Rodbell's Nobel lecture of 1994 for a greater description of their subsequent work).
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The chief events of endocannabinoids in cancer cell proliferation are reported highlighting the correspondent signalling involved in tumour processes: regulation of adenylyl cyclase, cyclic AMP-protein kinase-A pathway and
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