Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A
neural oligopeptide that stimulates the release ofgastrin
Etymologies
Sorry, no etymologies found.
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Examples
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My group demonstrated that the receptors for LH-RH, somatostatin and bombesin are present in various tumors, including human prostatic, mammary, endometrial and ovarian cancers.
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Based on this demonstration of receptors for peptides in various tumors, I started in 1995 the development of modern cytotoxic analogs of LH-RH, bombesin and somatostatin, which can be targeted to peptide receptors on various primary cancers and their metastases.
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My group synthesized several new classes of antitumor peptides such as LH-RH antagonists, somatostatin analogs, bombesin/GRP antagonists, GH-RH antagonists and targeted cytotoxic analogs of LH-RH, bombesin and somatostatin.
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My group also developed bombesin antagonists aimed at decreasing
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Ohki-Hamazaki H, Wada K (2000) Differential effects of social isolation upon body weight, food consumption, and responsiveness to novel and social environment in bombesin receptor subtype-3 (BRS-3) deficient mice.
PLoS ONE Alerts: New Articles Alessandro Bartolomucci et al. 2009
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They also managed to make mice immune to bombesin by slightly altering the structure of their GRPR protein.
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Nieminen O, Falkenberg M, Auvinen S (1988) Localization and development of bombesin / GRP-like immunoreactivity in the rat central nervous system.
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A lot of research has focused on a separate group of spinal cells called STT neurons that aren't affected by bombesin, and that are involved in both itch and pain.
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Anastasi A, Erspamer V, Bucci M (1971) Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes.
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• Includes (among others) cholecystokinin, amylin, glucagon-like-peptide 1 (GLP-1), enterostatin, and bombesin • Adiposity hormones • Long-term • Related to energy stores •
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