from The American Heritage® Dictionary of the English Language, 4th Edition
- n. A poisonous, pale-yellow alkaloid, C22H25NO6, obtained from the autumn crocus and used in plant breeding to induce chromosome doubling and in medicine to treat gout.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A highly toxic alkaloid, chemical formula C22H25NO6, originally extracted from plants of the genus Colchicum and formerly used to treat rheumatic complaints, now used mainly in the treatment of gout.
from the GNU version of the Collaborative International Dictionary of English
- n. A powerful vegetable alkaloid, C17H19NO5, extracted from the Colchicum autumnale, or meadow saffron, as a white or yellowish amorphous powder, with a harsh, bitter taste; -- called also colchicia.
from The Century Dictionary and Cyclopedia
- n. A poisonous alkaloid (C17H19NO5) obtained from the bulbs and seeds of plants of the genus Colchicum. It apparently represents the virtues of the crude drug.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. an analgesic drug derived from the saffron plant and used to treat gout
Standard treatment for gout includes fairly inexpensive nonsteroidal anti-inflammatory drugs like ibuprofen, steroids such as prednisone and another older medicine, called colchicine.
Treatment includes a non-steroidal anti-inflammatory drug (NSAID) when symptoms begin and a prescription medication called colchicine to help decrease uric acid levels and reduce pain, swelling and inflammation.
A drug called colchicine sometimes is used, but it tends to cause unpleasant side effects (nausea, vomiting, cramps, diarrhea) in about
Two little white pills called colchicine twice a day.
This year, for example, the FDA banned injectable versions of a gout drug called colchicine after receiving reports of 23 deaths.
One class of anti-inflammatory agents is microtubule-disrupting agents such as colchicine and vinblastine.
It is produced naturally in the purple flowers of meadow saffron (Colchium autumnale), whose seeds contain up to 0.8 percent colchicine. 1 This drug binds tublin and prevents its polymerization into microtubles. 2 Thus, it alters cellular division, intracellular transport, nuclear structure and cytoplasmic motility. 3 In gout, colchicine decreases the inflammatory response to urate crystals in joint tissues.
F.F. was a 36 year old white married female with a schizoaffective disorder who presented to a hospital after an intentional ingestion of colchicine, fluphenazine, lorazepam, benztropine and ethanol.
Plasma levels of colchicine after oral administration of a single dose.
In addition, adult respiratory distress syndrome has been reported. 10 Cardiovascular instability with severe hypotension and metabolic acidosis may predominate due to the volume depletion, cardiac failure and arrhythmias. 13 Oliguric renal failure develops due to pre-renal azotemia, myoglobinuria and a direct toxic effect of colchicine on the renal tubules.