Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun chemistry A
dimer derived from two identicalmonomers
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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IL-10 is an acid-sensitive, noncovalent homodimer of two interpenetrating polypeptide chain.
FreshPatents.com: Notable Patent Applications - 07/22/2010 2010
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The authors provided consistent evidence that the PORE region of SPP1 is a target for the homodimer of
PLoS ONE Alerts: New Articles Simone Pacini et al. 2010
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GLB-1* displays the classical three-over-three alfa helical sandwich of vertebrate globins, assembled in a homodimer associated through facing E - and F-helices.
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Professor of Medicine & Oncology at Hershey Medical Center / Penn State University reported on a study (the "Lipton Study") that assessed HERmark as a means to measure HER2 total protein and homodimer levels and to predict the response to treatment with Herceptin® (trastuzumab) in patients with metastatic breast cancer.
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At San Antonio, in an oral presentation, entitled "HER2 Protein expression and homodimer levels predict response to trastuzumab in centrally tested FISH-positive metastatic breast cancer patients," Allan Lipton M.D.,
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Conduct additional studies in both metastatic and adjuvant breast cancer using an expanded menu of VeraTag assays (which may include: HER2 total protein and homodimer, HER1 total protein and homodimer, HER3 total protein, HER1: 2 and HER2: 3 heterodimers, HER3-PI3K, and p95) to investigate why patients fail targeted therapies, and thus to understand how targeted inhibitors of the EGFR-family of receptors might be combined for better patient outcomes.
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Incorporate into HERmark, to supplement the current measurements of HER2 total protein and HER2: HER2 homodimer levels, at least one additional marker of potential resistance to HER2 antagonists such as trastuzumab.
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Initially, an FA binds with high affinity to one COX site of an unoccupied homodimer.
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HERmark provides accurate and quantitative measurements of HER2 total protein levels and HER2: HER2 homodimer levels.
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Analysis of HER2 status by HERmark in approximately 900 patient samples from the FINHER study of Herceptin in the adjuvant setting to assess the relationship of HER2 protein and HER2: HER2 homodimer measurements with clinical outcomes.
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