Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry, genetics
metabolomics
Etymologies
Sorry, no etymologies found.
Support
Help support Wordnik (and make this page ad-free) by adopting the word metabonomics.
Examples
-
In this regard, metabonomics, that is the study of complex metabolite profiles in biological samples, may provide a systems approach to understand the global metabolic regulation of the organism in relation to this peculiar pathology.
Naturejobs - All Jobs R Calvani 2010
-
NMR and MS-based metabonomics were employed to study global changes in metabolism due to the chocolate consumption.
How dark chocolate helps ease emotional stress - latest scientific evidence 2009
-
The development of "omic" technologies has evolved into three scientific disciplines: genomics which is defined as the study of genes and their function; proteomics which is defined as the study of the full set of proteins encoded by a genome; and metabonomics which is defined as the study of the total metabolite pool.
-
Today, however, the young field of computational biology offers the possibility that, with advances in computational biology's subdisciplines (e.g., genomics, proteomics, and metabonomics), scientists may have the ability to develop a more detailed understanding of the risks posed by a much larger number of chemicals.
-
The food giant and the university have been working together for several years in the field of metabonomics, which seeks to understand and quantify how metabolism is affected by dietary inputs.
DairyReporter RSS 2009
-
I would also like to see an example of metabonomics (metabolomics) NMR taken from the literature, but that can wait for the next version.
Citizendium, the Citizens' Compendium - Recent changes [en] 2009
-
The food giant and the university have been working together for several years in the field of metabonomics, which seeks to understand and quantify how metabolism is affected by dietary inputs.
NutraIngredients RSS 2009
-
I would also like to see an example of metabonomics (metabolomics) NMR taken from the literature, but that can wait for the next version.
Citizendium, the Citizens' Compendium - Recent changes [en] 2009
-
I would also like to see an example of metabonomics (metabolomics) NMR taken from the literature, but that can wait for the next version.
Citizendium, the Citizens' Compendium - Recent changes [en] 2009
-
Her current research in bioanalytical chemistry involves the development and application of microcoil NMR probes, heparin and heparan sulfate characterization and biochemistry, application of metabonomics for chemical genomics studies in Arabidopsis thaliana and in rice, and NMR measurements to investigate ligand-protein interactions.
Daily Headlines 2009
Prolagus commented on the word metabonomics
Organisms often respond in complex and unpredictable ways to stimuli that cause disease or injury. By measuring and mathematically modelling changes in the levels of products of metabolism found in biological fluids and tissues, metabonomics offers fresh insight into the effects of diet, drugs and disease.
And in case you're wondering...
What's the difference between metabonomics and metabolomics?
The distinction is mainly philosophical, rather than technical. Metabonomics broadly aims to measure the global, dynamic metabolic response of living systems to biological stimuli or genetic manipulation. The focus is on understanding systemic change through time in complex multicellular systems. Metabolomics seeks an analytical description of complex biological samples, and aims to characterize and quantify all the small molecules in such a sample. In practice, the terms are often used interchangeably, and the analytical and modelling procedures are the same.
("News and Views Q&A", Nature 455, 1054-1056 (23 October 2008))
October 23, 2008
sionnach commented on the word metabonomics
I don't think they are completely interchangeable, however. For instance, if I wanted to characterize the metabolic fate of an exogenously administered substance, such as a xenobiotic drug or a recombinant therapeutic protein, it seems pretty clear that I would be trying to elucidate the metabolomic, not the metabonomic, response to the intervention.
It is a misconception to think that either approach might be concerned only with the quantitation of small molecules in the various biological matrices - if the substance administered were a macromolecule, such as a monoclonal antibody, it may well be of interest to track degradation products that are also macromolecules. And, for safety purposes, one will need to have developed an assay to detect potential antibodies to the administered protein.
I have yet to see a convincing example of this kind of modeling in action. But I've reviewed dozens of papers in which investigators attempted to cover over deep flaws in the modeling with a kind of boyishly enthusiastic wishful thinking.
To which one can only answer, with regret: GIGO.
October 23, 2008