Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry Any
protein that is cleaved by aconvertase to form a smaller protein or biologically-activepolypeptide
Etymologies
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Examples
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Indeed, this consensus sequence could be found in the premature, inactive proform of several proteins, which are processed by serine endoproteases, namely proprotein convertases (PCs).
PLoS ONE Alerts: New Articles Katarina Hajdin et al. 2010
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This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE).
PLoS ONE Alerts: New Articles Gang Wu et al. 2010
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Kotorashvilli A, Russo S, Mulugeta S, Guttentag S, Beers M. Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY mediated association with Nedd4-2 ubiquitin ligases.
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Siegfried G, Basak A, Cromlish JA, Benjannet S, Marcinkiewicz J, et al. (2003) The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.
PLoS ONE Alerts: New Articles Katarina Hajdin et al. 2010
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Furthermore, this work demonstrates that specific targeting of membrane-bound furin in tumors is possible for and suggests that RMS and other tumors might benefit from proprotein convertases targeted drug delivery.
PLoS ONE Alerts: New Articles Katarina Hajdin et al. 2010
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CDKN2A and N-Ras genes, we found that inhibition of the proprotein convertases
Elites TV PLoS ONE 2010
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Alnylam has an ongoing development program focused on using RNAi therapeutics targeting proprotein convertase subtilisin/kexin type 9, or PCSK9, as a novel strategy for reducing LDL (or "bad") cholesterol.
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R, Seidah NG, Prat A (2009) The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.
PLoS ONE Alerts: New Articles Katarina Hajdin et al. 2010
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Scamuffa N, Siegfried G, Bontemps Y, Ma L, Basak A, et al. (2008) Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.
PLoS ONE Alerts: New Articles Katarina Hajdin et al. 2010
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Lebel A, McMahon S, Fournier I, Fugere M, et al. (2003) TACE/ADAM-17 maturation and activation of sheddase activity require proprotein convertase activity.
PLoS ONE Alerts: New Articles Katarina Hajdin et al. 2010
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