Definitions

from The American Heritage® Dictionary of the English Language, 5th Edition.

  • noun Any of various glycoproteins that have glycosaminoglycan chains attached by covalent bonds to the protein, usually found in the extracellular matrix of connective tissue.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry Any of many glycoproteins that have heteropolysaccharide side chains

Etymologies

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Examples

  • Should the GA wish to ensure such adherence, I would recommend proteoglycan therapy for the participants.

    Starfish 1999

  • During labour the uterus can be divided into two regions, the upper, muscular region and the lower region which generally acts to provide a passive fibromuscular birth canal. cervix consists largely of fibrous collagen in a proteoglycan matrix.

    Conservapedia - Recent changes [en] DanielPulido 2010

  • Campos-Xavier AB, Martinet D, Bateman J, Belluoccio D, Rowley L, et al. (2009) Mutations in the heparan-sulfate proteoglycan glypican 6 (GPC6) impair endochondral ossification and cause recessive omodysplasia.

    PLoS ONE Alerts: New Articles Dan E. Arking et al. 2010

  • It is based on increased proteoglycan loss as well as attachment and invasion of inflammatory tissue into the cartilage, which leads to its structural disintegration.

    PLoS ONE Alerts: New Articles Gang Wu et al. 2010

  • Wu YP, Siao CJ, Lu W, Sung TC, Frohman MA, et al. (2000) The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate.

    PLoS ONE Alerts: New Articles Hongqi Xin et al. 2010

  • This enhances proteoglycan synthesis, the molecule responsible for keeping articular joint cartilage lubricated.

    Wil's Ebay E-Store amp;34; 2010

  • The GPC5 gene encodes glypican 5, one of the six members of the heparan sulfate proteoglycan (HSPG) family.

    Newswise: Latest News 2010

  • Emmetsberger J, Bukhari N, Zhang Y, Levine JM, et al. (2008) tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2.

    PLoS ONE Alerts: New Articles Hongqi Xin et al. 2010

  • Chatterjee N, Trotter J (2005) NG2-expressing cells in the nervous system: role of the proteoglycan in migration and glial-neuron interaction.

    PLoS ONE Alerts: New Articles 2009

  • Interleukin-1 in particular contributes to disc degeneration by inducing enzymes that destroy proteoglycan and is involved in the mediation of pain.

    Recently Uploaded Slideshows 2009

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