from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. The condition of having an abnormally high number of thrombocytes (platelets) in the bloodstream; can give a predisposition to thrombosis
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- n. increase in the number of platelets in the blood which tends to cause clots to form; associated with many neoplasms and chronic infections and other diseases
Sorry, no etymologies found.
Abrahams believes the company is undervalued, based mostly on 424s potential in treating myelofibrosis, Polycythemia vera, and Essential thrombocytosis, and in part, on the early promise of rheumatoid arthritis drug INCB28050.
It's also frequently found in patients with essential thrombocytosis, an overproduction of platelets that usually requires no treatment and can be addressed with blood-thinners when patients have symptoms.
Aside from agranulocytosis, the bone marrow and blood show a number of other abnormalities (including maturational arrest of neutrophil precursors at the promyelocyte stage, absolute monocytosis, eosinophilia and thrombocytosis).
For example, patients with high cholesterol levels (hypercholesterolemia) have more peripheral blood cells and increased platelet levels (thrombocytosis).
Essential thrombocytosis is an overproduction of these clotting cells.
Last year, Fulgencio Garcia was diagnosed with myelofibrosis, an aggressive form of leukemia, on top of his existing essential thrombocytosis.
"JAK-inhibiting drugs are now moving into clinical trials for treatment of such adult myeloproliferative diseases as polycthemia vera, essential thrombocytosis and primary myelofibrosis," Downing said.