Definitions
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- noun biochemistry A
protein important in thecontraction of striatedmuscle tissues.
Etymologies
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Examples
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Researchers engineered a polymer to reproduce the properties of titin - a protein which largely determines the elastic properties of muscle.
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The authors wrote that synthetic biomaterials display the unique multifunctional characteristics of titin, acting like a spring with high resilience at low strain and as a shock-absorb at high strains.
PhysOrg.com - latest science and technology news stories 2010
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"A hallmark of titin-like proteins is that they unfold under a stretching force to dissipate energy and prevent damage to tissues by over-stretching," said co-author John
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The team engineered a synthetic protein to reproduce the molecular structure of titin, the muscle protein "that largely governs the elastic properties of muscle," according to the Nature article.
PhysOrg.com - latest science and technology news stories 2010
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Trombitas K, Witt CC, Labeit S, et al. (2002) Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness.
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The integrated optical density (OD) of N2BA titin, N2B titin, total titin (N2BA+N2B), and myosin heavy chain (MHC) were determined at each lane.
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N2BA: the large more compliant isoform (3300 kDa) of titin, N2B: the smaller stiffer isoform (3000 kDa) of titin, nebulin
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The increase in the interstitial protein collagen and decrease in the sarcomeric proteins MHC and titin in hypoxic hearts might account for the observed changes
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D, gel electrophoresis and densitometric analysis showing lowered titin protein levels and its isoforms in hypoxic E20 chick embryo hearts.
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Hypoxic chick embryos displayed severe LV dilatation just prior to hatching, which was accompanied by a reduced LV wall mass, increased apoptosis, as well as a lowered cardiac content of the sarcomeric proteins MHC and titin.
케발컨 commented on the word titin
Titin is the longest word in the English language. It's real name is:
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alanylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutami nylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalany lglycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylh istidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglut aminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisol eucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysyli soleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmethionyll eucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonyl arginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylalan 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ucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphenylalany lglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionyl glutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylprolylaspartyla lanylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylgl ycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylaspar aginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylgluta myltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylseryla lanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylal anylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylas paraginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanyl valylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreon ylserylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspart ylprolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparagi nylglutaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutamin ylvalylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylgl utaminylserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginy ltyrosylasparaginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthr eonylphenylalanylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasp araginylglutaminylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthr eonylarginylarginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparagi nylisoleucylasparaginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyr osylasparaginylglutaminylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyl tryptophylthreonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylph enylalanylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylargi nylglutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylar ginylalanylglycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylas paraginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolyl leucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanyl alanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylv alyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysyl methionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalan ylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalyl phenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparagi nylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylgl utaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylg lutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenylalanyl 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larginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglu tamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyl lysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisole ucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalan ylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminyl histidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylph enylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisole ucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylal anylaspartylprolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglyc ylasparaginylglutaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreon ylglutaminylvalylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalan ylprolylglutaminylserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyr osylarginyltyrosylasparaginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucy lglycylthreonylphenylalanylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylg lutamylasparaginylglutaminylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylasparty lalanylthreonylarginylarginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalan ylasparaginylisoleucylasparaginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycy lleucyltyrosylasparaginylglutaminylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycyll eucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylser ylleucylphenylalanylalanylmethionylthreonylthreonylglutaminylarginyltyrosylglutamylserylleucylphenyl alanylalanylglutaminylleucyllysylglutamylarginyllysylglutamylglycylalanylphenylalanylvalylprolylphen ylalanylvalylthreonylleucylglycylaspartylprolylglycylisoleucylglutamylglutaminylserylleucyllysylisol eucylaspartylthreonylleucylisoleucylglutamylalanylglycylalanylaspartylalanylleucylglutamylleucylglyc ylisoleucylprolylphenylalanylserylaspartylprolylleucylalanylaspartylglycylprolylthreonylisoleucylglu taminylasparaginylalanylthreonylleucylarginylalanylphenylalanylalanylalanylglycylvalylthreonylprolyl alanylglutaminylcysteinylphenylalanylglutamylmethionylleucylalanylleucylisoleucylarginylglutaminylly sylhistidylprolylthreonylisoleucylprolylisoleucylglycylleucylleucylmethionyltyrosylalanylasparaginyl leucylvalylphenylalanylasparaginyllysylglycylisoleucylaspartylglutamylphenylalanyltyrosylalanylgluta minylcysteinylglutamyllysylvalylglycylvalylaspartylserylvalylleucylvalylalanylaspartylvalylprolylval ylglutaminylglutamylserylalanylprolylphenylalanylarginylglutaminylalanylalanylleucylarginylhistidyla sparaginylvalylalanylprolylisoleucylphenylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartyl aspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylth reonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparaginylarginyl alanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasp araginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylas partylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucyl serylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisol eucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutamin ylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolyl serylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisole ucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginylglutaminyl phenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutam inylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylseryl threonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylaspar aginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylal anylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylgluta minylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginyla rginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucyla sparaginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparagin ylglutaminylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthr eonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylala nylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginylglutaminyl isoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylgl ycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhist idylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutami nylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleuc ylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisol eucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleuc ylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonylarg inylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylalanyll eucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginylvalylcyste inylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylglutaminylgluta minylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylglutaminylvaly ltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenylalanylprolylglycyla spartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspartylprolylleucylis oleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylasparaginylarginyl isoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthreonylthreonylala nylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalanylthreonylvaly lalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylglutamylleucy lvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphenylalanylgl utamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinmethionylglu taminylarginyltyrosylglutamylserylleucylphenylalanylalanylisoleucylcysteinylprolylprolylaspartylalan ylaspartylaspartylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglycylarginylglycy ltyrosylthreonyltyrosylleucylleucylserylarginylalanylglycylvalylthreonylglycylalanylglutamylasparagi nylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysylglutamyl tyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphenylalanylglycylisoleucylserylalan ylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanylalanylglycylalany lisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucylglutamylglutaminylhistidylaspar aginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylleucyllysylvalylphenylalanylval ylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylseryltyrosylserylisoleucylthreonyls erylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylserylvalyltryptophylalanylaspartylp rolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonylserylserylleucylglycylasparaginyl glutaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylarginylthreonylthreonylglutaminylv alylglutaminylglutaminylphenylalanylserylglutaminylvalyltryptophyllysylprolylphenylalanylprolylgluta minylserylthreonylvalylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysylvalyltyrosylarginylty rosylasparaginylalanylvalylleucylaspartylprolylleucylisoleucylthreonylalanylleucylleucylglycylthreon ylphenylalanylaspartylthreonylarginylasparaginylarginylisoleucylisoleucylglutamylvalylglutamylaspara ginylglutaminylglutaminylserylprolylthreonylthreonylalanylglutamylthreonylleucylaspartylalanylthreon ylarginylarginylvalylaspartylaspartylalanylthreonylvalylalanylisoleucylarginylserylalanylasparaginyl isoleucylasparaginylleucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglycylleucyltyrosy lasparaginylglutaminylasparaginylthreonylphenylalanylglutamylserylmethionylserylglycylleucylvalyltry ptophylthreonylserylalanylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucylpheny lalanylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartylaspartylaspartylleucylleucylarginyl glutaminylisoleucylalanylseryltyrosylglycylarginylglycyltyrosylthreonyltyrosylleucylleucylserylargin ylalanylglycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylaspar aginylhistidylleucylvalylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleu cylglutaminylglycylphenylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylala nylisoleucylaspartylalanylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvaly llysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmet hionylleucylalanylalanylleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylt hreonylarginylacetylseryltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphe nylalanylleucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginyl valylcysteinylthreonylserylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylgluta minylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylglut aminylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenylalanylpro lylglycylaspartylvalyltyrosyllysylvalyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspartylprol ylleucylisoleucylthreonylalanylleucylleucylglycylthreonylphenylalanylaspartylthreonylarginylasparagi nylarginylisoleucylisoleucylglutamylvalylglutamylasparaginylglutaminylglutaminylserylprolylthreonylt hreonylalanylglutamylthreonylleucylaspartylalanylthreonylarginylarginylvalylaspartylaspartylalanylth reonylvalylalanylisoleucylarginylserylalanylasparaginylisoleucylasparaginylleucylvalylasparaginylglu tamylleucylvalylarginylglycylthreonylglycylleucyltyrosylasparaginylglutaminylasparaginylthreonylphen ylalanylglutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalanylprolylalanyltitinme thionylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylmethionylthreonylthreonylglutami nylarginyltyrosylglutamylserylleucylphenylalanylalanylglutaminylleucyllysylglutamylarginyllysylgluta mylglycylalanylphenylalanylvalylprolylphenylalanylvalylthreonylleucylglycylaspartylprolylglycylisole ucylglutamylglutaminylserylleucyllysylisoleucylaspartylthreonylleucylisoleucylglutamylalanylglycylal anylaspartylalanylleucylglutamylleucylglycylisoleucylprolylphenylalanylserylaspartylprolylleucylalan 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onylglycylalanylglutamylasparaginylarginylalanylalanylleucylprolylleucylasparaginylhistidylleucylval ylalanyllysylleucyllysylglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylglycylphen ylalanylglycylisoleucylserylalanylprolylaspartylglutaminylvalyllysylalanylalanylisoleucylaspartylala nylglycylalanylalanylglycylalanylisoleucylserylglycylserylalanylisoleucylvalyllysylisoleucylisoleucy lglutamylglutaminylhistidylasparaginylisoleucylglutamylprolylglutamyllysylmethionylleucylalanylalany lleucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylalanylalanylthreonylarginylacetylser yltyrosylserylisoleucylthreonylserylprolylserylglutaminylphenylalanylvalylphenylalanylleucylserylser ylvalyltryptophylalanylaspartylprolylisoleucylglutamylleucylleucylasparaginylvalylcysteinylthreonyls erylserylleucylglycylasparaginylglutaminylphenylalanylglutaminylthreonylglutaminylglutaminylalanylar 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August 1, 2008
케발컨 commented on the word titin
it's actually even larger, i can't fit it all here
August 1, 2008
bilby commented on the word titin
Bravo.
April 11, 2011
yarb commented on the word titin
There is an even shorter form: spam.
April 11, 2011
fondren commented on the word titin
The word is a play on the Greek, "titan," a giant being, because the molecule of this protein is large. The discoverers of the molecule gave it this name in their scientific paper
April 29, 2015