Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A polypeptide consisting of 76 amino acids and found in all eukaryotic cells, whose main cellular function is to tag other proteins that will undergo degradation.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A small
polypeptide present in thecells of alleukaryotes ; it plays a part in modifying and degradingproteins
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
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Examples
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Consequently, degradation of both abnormal and normal shortlived proteins was also inhibited, demonstrating that the same enzyme that is involved in ubiquitin activation for histone modification, is also involved in activation of ubiquitin for modification of substrates destined for degradation.
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(and I believe that in several others as well) that ubiquitin was limited to eukaryotes, and its apparent presence in bacteria was due to the contamination of the bacterial extract with the yeast extract in which the bacteria were grown: growing the bacteria in a synthetic medium containing carbon (glucose) and nitrogen (ammonium chloride) sources and vitamins resulted in "disappearance" of ubiquitin from the preparation.
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While it appeared that the term ubiquitin was not justified anymore, as it is clearly not ubiquitous, we stopped using the term APF-1 and adopted the term ubiquitin for the modifying protein in the newly discovered proteolytic system.
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Since the molecule was subsequently found in numerous different tissues and organisms but not in bacteria it was given the name ubiquitin (from Latin ubique, "everywhere") (fig. 1).
The Nobel Prize in Chemistry 2004 - Information for the Public 2004
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By using antibodies to ubiquitin, ubiquitin-protein-conjugate could be isolated from cells where the cell proteins had been pulse-labelled with a radioactive amino acid not present in ubiquitin.
The Nobel Prize in Chemistry 2004 - Information for the Public 2004
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Recently, scientists discovered that a protein called ubiquitin is involved in some cases of FTD.
WN.com - Articles related to Scientists uncover mysterious workings of cholera bacteria 2010
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The tagging reaction is catalyzed by enzymes called ubiquitin ligases.
WN.com - Articles related to Scientists uncover mysterious workings of cholera bacteria 2010
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The tagging reaction is catalyzed by enzymes called ubiquitin ligases.
WN.com - Articles related to Scientists uncover mysterious workings of cholera bacteria 2010
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Recently, scientists discovered that a protein called ubiquitin is involved in some cases of FTD.
WN.com - Articles related to Scientists uncover mysterious workings of cholera bacteria 2010
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Recently, scientists discovered that a protein called ubiquitin is involved in some cases of FTD.
WN.com - Articles related to Scientists uncover mysterious workings of cholera bacteria 2010
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