Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- verb biology To
increase the number of cellreceptors by usingupregulation .
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
Support
Help support Wordnik (and make this page ad-free) by adopting the word upregulate.
Examples
-
"upregulate," or churn out, genes that make molecules that signal the immune system to throttle back; and they can "downregulate," or reduce the production of, genes that make molecules that carry signals between immune cells.
-
These in turn upregulate negative genes that produce pro-inflammatory cytokines that damage skin cells.
Forever Young M.D. Nicholas Perricone 2010
-
As a dermatologist, I have been delighted to learn that when these nutrients are applied topically, they can upregulate the expression of genes that decrease and/or prevent inflammation.
Forever Young M.D. Nicholas Perricone 2010
-
When these nutrients upregulate gene expression, the following benefits result:
Forever Young M.D. Nicholas Perricone 2010
-
We now know that many of these phytonutrients also work through other mechanisms, specifically the expression of genes that can upregulate the natural protective mechanisms of our cells.
Forever Young M.D. Nicholas Perricone 2010
-
These in turn upregulate negative genes that produce pro-inflammatory cytokines that damage skin cells.
Forever Young M.D. Nicholas Perricone 2010
-
When phytonutrients and other molecules that contain the Michael acceptor–like pharmacophore upregulate the transcription factor NRF2, more than a dozen protective anti-inflammatory proteins in the cell are activated.
Forever Young M.D. Nicholas Perricone 2010
-
When applied topically, they function as a powerful anti-inflammatory agent, partially because of their ability to upregulate NRF2, which provides the skin with many benefits, including increased radiance, decreased pore size, and, with continued use, a reduction in fine lines and discolorations.
Forever Young M.D. Nicholas Perricone 2010
-
Upon activation, these transcription factors translocate to the nucleus of the cell, where they attach to receptor sites on the genes and upregulate, or turn on, their expression.
Forever Young M.D. Nicholas Perricone 2010
-
At the same time, the molecules that we thought were just antioxidants bind to and turn off transcription factors that are known to upregulate more than a hundred inflammation-generating genes, resulting in damage to all of our organ systems.
Forever Young M.D. Nicholas Perricone 2010
Comments
Log in or sign up to get involved in the conversation. It's quick and easy.