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  • Zika, which was discovered incidentally in Uganda in 1947 in the course of mosquito and primate surveillance,1 had until now remained an obscure virus confined to a narrow equatorial belt running across Africa and into Asia. The virus circulated predominantly in wild primates and arboreal mosquitoes such as Aedes africanus and rarely caused recognized “spillover” infections in humans, even in highly enzootic areas.

    . . .

    Through early epidemiologic surveillance and human challenge studies, Zika was characterized as a mild or inapparent denguelike disease with fever, muscle aches, eye pain, prostration, and maculopapular rash.


    Zika Virus in the Americas — Yet Another Arbovirus Threat

    Anthony S. Fauci, M.D., and David M. Morens, M.D.

    January 13, 2016DOI: 10.1056/NEJMp1600297

    January 14, 2016