Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- adjective Of or relating to a mutation that changes a codon for one amino acid into a codon for a different amino acid.
from The Century Dictionary.
- To give a wrong sense or meaning to.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biology A damaged DNA sequence that is meaningful but has an incorrect meaning, with the result that its products do not do what they are supposed to do.
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
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Examples
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Genetic diseases are often caused by a specific type of genetic alteration called a missense mutation that makes cells add an incorrect amino acid into the protein chain.
PhysOrg.com - latest science and technology news stories 2010
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Genetic diseases are often caused by a specific type of genetic alteration called a missense mutation that makes cells add an incorrect amino acid into the protein chain.
Scientific Blogging 2010
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Genetic diseases are often caused by a specific type of genetic alteration called a missense mutation that makes cells add an incorrect amino acid into the protein chain.
PhysOrg.com - latest science and technology news stories 2010
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DDS: These individuals carry specific alterations known as missense mutations, mostly in exons 8 or 9 of one working copy of the WT1 gene.
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Three of these resulted in missense mutations in mitochondrially encoded NADH dehydrogenases 1, 2 and 4, and one caused a nonsense mutation in ATPase 6.
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The missense mutation resulted in inactivation of the autoglucosylation of glycogenin-1 that is necessary for the priming of glycogen synthesis in muscle.
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The missense mutation resulted in inactivation of the autoglucosylation of glycogenin-1 that is necessary for the priming of glycogen synthesis in muscle.
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GYG1, revealed a nonsense mutation in one allele and a missense mutation, Thr83Met, in the other.
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To confirm the HIF-1α-dependent regulation of 5-FU responsiveness and to further characterize the contribution of p53, we examined a second human gastric cancer cell line (MKN28), which carries a missense mutation in
PLoS ONE Alerts: New Articles Nadine Rohwer et al. 2010
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The missense mutation resulted in inactivation of the autoglucosylation of glycogenin-1 that is necessary for the priming of glycogen synthesis in muscle.
Prolagus commented on the word missense
A mutation that changes a single amino acid, with no effect on the rest of the amino acid sequence of the synthesized polypeptide.
September 20, 2009
sionnach commented on the word missense
as opposed to, e.g., a frame-shift mutation, which will generally screw up the entire remainder of the sequence
September 20, 2009
Prolagus commented on the word missense
Or e.g. a synonymous mutation, which is a mutation that does not change any amino acid and is therefore (considered) neutral.
March 16, 2011