disadvantage

from The American Heritage® Dictionary of the English Language, 5th Edition.

• noun An unfavorable condition or position.
• noun Something that places one in an unfavorable condition or position.
• noun Damage or loss, especially to reputation or finances; detriment.
• transitive verb To put at a disadvantage; hinder or harm.

from The Century Dictionary.

• To hinder or embarrass; do something prejudicial or injurious to; put at disadvantage.
• noun Absence or deprivation of advantage; that which prevents success or renders it difficult; any unfavorable circumstance or condition: as, the disadvantage of poverty or imperfect education.
• noun Loss; injury; prejudice to interest, reputation, credit, profit, or other good: as, to sell goods to disadvantage.
• noun Synonyms Detriment, injury, hurt, harm, damage, prejudice, drawback.

from the GNU version of the Collaborative International Dictionary of English.

• transitive verb To injure the interest of; to be detrimental to.
• noun Deprivation of advantage; unfavorable or prejudicial quality, condition, circumstance, or the like; that which hinders success, or causes loss or injury.
• noun Loss; detriment; hindrance; prejudice to interest, fame, credit, profit, or other good.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

• noun A weakness or undesirable characteristic; a con.
• noun A setback or handicap.
• verb transitive To place at a disadvantage.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

• verb put at a disadvantage; hinder, harm
• noun the quality of having an inferior or less favorable position